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Why Tirzepatide Works Better Than Diet Alone Restrictive dieting activates compensatory hunger hormones and metabolic adaptation, making long-term adherence difficult for most people

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Even at lower doses, microdosing may help curb hunger, minimize cravings, and encourage smaller meal sizes

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They found a correlation between attenuated dorsolateral PFC activity to high-caloric versus low-caloric food and reduced ghrelin levels in LSG patients after surgery (Li et al., 2019)

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